I am trying to update the style.css file via ftp but the changes are not reflecting on the front end of the site. I have emptied my caches several times and the changes still do not show up. I have re-downloaded the file and the changes that I made are still there. Is there something simple that I am missing? I am running the theme on a site in a multisite network.

Have you also cleared the cache from your caching plugin (in case you have one)? It’s the only thing I can think about. Not sure we can help you very much in this situation.

There is no caching plugin installed. I can update a php file and it will show changes but it won’t for a js or css.